What are the Similarities Between Adrenal Cortex and Adrenal MedullaĤ. The main difference between adrenal cortex and adrenal medulla is that adrenal cortex helps to release energy from proteins and fats for chronic responses whereas adrenal medulla helps to mediate acute responses. The adrenal medulla secretes epinephrine and norepinephrine. The adrenal cortex secretes glucocorticoids, mineralocorticoids, and androgens. Both adrenal cortex and adrenal medulla produce and secrete hormones. The outermost layer of the adrenal gland is called the adrenal cortex, and the innermost layer of the adrenal gland is called adrenal medulla. ![]() The adrenal gland consists of distinct zones or layers of cells. Main Difference – Adrenal Cortex vs Adrenal MedullaĪdrenal glands are situated on top of the kidney.
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